This expression means to make someone very angry. It alludes to an old medical theory: becoming hot with excitement or exertion was supposed to be the result of blood getting hot. Although this saying did not appear in print until 1848, the term 'the blood boils' dates from the seventeenth century.

Übersetzung:

jemandem kocht das Blut in den Adern

Gegenteil(e)

The opposite of "to make somebody's blood boil" is "to sober down".

Synonym(e):

You could also say: to make someone very angry.